Zyloprim Drug Uses

Zyloprim reduces the production of uric acid in your body. Zyloprim is used to treat gout, increased levels of uric acid caused by cancer treatment, and kidney stones that are caused by high levels of uric acid.

How Taken

Zyloprim comes as a tablet to take it orally. It usually is taken once a day, preferably after a meal. Drink at least eight glasses of water or other fluids each day while taking Zyloprim unless directed to do otherwise by your doctor. Avoid excessive amounts of vitamin C supplements or fruit juice while taking Zyloprim. Too much vitamin C may increase your chance of developing kidney stones.

Zyloprim Warnings/Precautions

Before taking Zyloprim, tell your doctor if you have kidney or liver disease. You may need a lower dose of Zyloprim or special monitoring during your therapy. Zyloprim is in the FDA pregnancy category C. This means that it is not known whether Zyloprim will harm an unborn baby. Do not take Zyloprim without first talking to your doctor if you are pregnant. Zyloprim passes into breast milk. Do not take Zyloprim without first talking to your doctor if you are breast-feeding a baby.

Zyloprim Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

Zyloprim Possible Side Effects

If you experience any of the following serious side effects, stop taking Zyloprim and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); blood in your urine or pain when you urinate; a rash; eye irritation; fever, chills, or joint aches; or severe nausea or vomiting. Other, less serious side effects may be more likely to occur. Continue to take Zyloprim and talk to your doctor if you experience upset stomach or diarrhea; headache, dizziness, or drowsiness; or an acute attack of gouty arthritis. Side effects other than those listed here may also occur. Talk to your doctor about any reaction that seems unusual or that is especially bothersome.

Zyloprim Storage

Store at 15-25°C (59-77°F) in a dry place and protect from light.

Zyloprim Overdose

Seek emergency medical attention. Symptoms of Zyloprim overdose are not known.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Zyloprim may cause drowsiness. If you experience drowsiness, avoid these activities. Avoid alcohol. It may worsen your condition. Follow your doctor's recommendations about diet.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The aim of our study was to determine the prevalence of psoriatic arthritis in the patients with psoriasis and to analyze retrospectively the results of a 34-year multidisciplinary management of the patients with psoriatic arthritis. METHODS: The study included 162 out of 183 treated patients with psoriatic arthritis, aged 48 +/- 15 years. All the patients satisfied the current diagnostic criteria for psoriasis and psoriatic arthritis according to the American College of Rheumatology. RESULTS: Psoriatic arthritis developed in 183 (9.3%) out of 1976 patients with psoriasis. Time interval for establishing the diagnosis was 4 years. A positive family history of the disease had 15.0% of the studied patients. Its onset was most often at 42 years of age in 70.4% of the cases, and 2 months to 59 years after the appearance of psoriasis. Psoriatic arthritis without psoriasis appeared in 1.8% of the patients. A severe form of arthritis had 64.2% of the patients, mainly the patients with scalp psoriasis (chi2 = 3.2; p < 0.05). Nail changes had 35% of the patients. Distal interphalangeal joints were involved in 63.6%, axial skeleton in 36.4%, oligoarthritis in 45.0%, polyarthritis in 55.0%, and mutilating form in 6.8% of the patients. Elevated Erythrocyte Sedimentation Rate was reveald in 61.7% of the patients. Immunoglobulin M (IgM) rheumatoid factor was altered in 4.3% of the patients. The human leukocyte antigen (HLA) typing in the 28 patients were: A2 32.0%, A3 18.0%, Al and A9 14.0%, A28 and A29 3.5%, B8 and B16 14.0%, B5 and B12 11.0%, B13, B15, B18, B27 and B35 7.0%. Radiologic changes were most often in hand and foot joints, less frequently in the knees and quite infrequently in hips and shoulders joints. Sacroiliitis was found in 46.4% of the patients. Psoriasis was treated with topical corticosteroids and salicylic ointments in all the patients, ultraviolet (PUVA therapy) in 5.6% and retinoids in 4.3% of them. Artrithis was treated with nonsteroidal anti-inflammatory drugs, with systemic corticosteroids 41.3% and with disease modified antirheumatic drugs, most frequently methotrexate, 59.9% of the patients. Radionuclide synovectomy was performed in 6.8%, surgery in 6.2% and physical therapy in all the patients. CONCLUSION: Psoriatic arthritis developed in 9.3% of the psoriatic patients. Time interval for establishing the diagnosis was long, and there were no specific laboratory findings. All the synovial joints could be involved in the psoriatic process. Scintigraphy should be used only in case of early suspected sacroiliitis. The treatment of psoriatic arthritis was the teamwork between the dermatologist, rheumatologist, physiatrist and orthopedic surgeon.

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